Characterizing pathologies to better understand them

"The study of the gene expression profile of lymphomas using RT-MIS analysis ( lymphosign has been routinely integrated into the laboratory and allows us to finely evaluate the nosological subtype of mature lymphoid hematological diseases. 

This analysis is a particularly useful complement for the anatomo-biological comparisons of complex cases and provides us with information different from high-throughput sequencing analyses. 

The easyness of the kit from a technical and analytical point of view and its versatility allowed us to easily integrate it into the range of analyzes carried out in our molecular biology laboratory."

Dr Sylvain CARRAS, MD - PhD at CHU Grenoble Alpes, France

"The easyness and robustness of the Lymphosign kit allowed us to effectively integrate it with our lymphopanel NGS, thus facilitating the pathologist's work for the diagnosis of complex cases.

We initially opted for RT-MLPA, which convinced us for the study of large B-cell lymphomas. However, the Lymphosign kit made it possible to extend the expression analysis to small cell B lymphomas and the main T lymphoma entities.

In addition, the combination of expression analysis and the study of hotspot mutations makes it possible, in certain cases, to reduce the need for NGS analysis."

Dr Audrey Gros, MCU-PH, Tumor Biology and Tumor Bank Department - Bordeaux University Hospital; Inserm Unit U1312 - BRIC (BoRdeaux Institute of onCology) - Team 5 Trio2 (Translational research in skin cancer and rare skin diseases)", France

"I'm a clinical hematologist at the Henri Becquerel Center in Rouen, and I'm also involved in translational research at INSERM Unit U1245 in Professor JARDIN's team. I have carried out several research projects on the molecular characterization of lymphomas, using RT-MLPA with the LymphoSign signature to study the gene expression profile of lymphomas. 

At the Henri Becquerel center, the technique LymphoSign test is available in routine use to help the diagnosis of lymphomas and proves to be very valuable for the accurate classification of lymphomas, and also to assist the pathologist in diagnosing difficult cases, which are not so rare in practice. 

I'm particularly interested in primary B lymphomas of the mediastinum (PMBL), which are a unique and rare entity of aggressive mature B-cell lymphoma, preferentially affecting young patients with a female predominance. Diagnosis of these lymphomas is difficult, and the LymphoSign technique is in my view a very useful companion test for accurately identifying and diagnosing these cases, with strong clinical consequences since the treatment and prognosis of these lymphomas is quite different from other aggressive B-cell lymphomas."

Dr Vincent CAMUS, clinical hematologist at the Henri Becquerel Center in Rouen, France